Environment, Brain, and Behavior (EBB) Lab

The Environment, Brain, and Behavior (EBB) Lab for Developmental Visual-Spatial and Learning Disorders is located in the Division of Child and Adolescent Psychiatry at Columbia University Medical Center in New York City. Directed by Dr. Amy Margolis, the EBB lab studies the neurobiology of Non-Verbal Learning Disorder and how exposure to neurotoxic chemicals may affect neurodevelopment and manifest as learning and social problems. The EBB Lab uses neuroimaging to identify biomarkers of exposure to neurotoxicants and aid in the development of prevention and intervention programs to improve children's health outcomes.  

Recently Published Work

NVLD

Environment

Altered structure and functional connectivity of the hippocampus are associated with social and mathematical difficulties in nonverbal learning disability [link]

  • Despite the overlap between behaviors supported by the hippocampus and impairments in NVLD, the structure and function of the hippocampus in NVLD has not been studied.

  • Here we show that, in children with NVLD, reduced hippocampal volume associated with worse mathematical problem solving

  • And we show that greater connectivity was associated with fewer social problems among children with NVLD but not TD children

Associations between Amygdala-Prefrontal Functional Connectivity and Age Depend on Neighborhood Socioeconomic Status [link]

  • Early life stress has been shown to accelerate the development of frontolimbic resting-state functional connectivity, but less is known about the effects of socioeconomic disadvantage

  • Here we have shown that amygdala subregional-vmPFC RSFC depends on neighborhood socioeconomic status

  • We have shown that children from less advantaged neighborhoods had, on average, near-zero amygdala-vmPFC RSFC and a greater likelihood of having negative connectivity than advantaged children

Ramphal B, DeSerisy M, Pagliaccio D, Raffanello E, Rauh V, Tau G, Posner J, Marsh R, Margolis AE. (2020). Associations between Amygdala-Prefrontal Functional Connectivity and Age Depend on Neighborhood Socioeconomic Status, Cerebral Cortex Communications, 1.